Random Thoughts

[spoon]

That it's a safe drug (which he knows copaxone is too) and that it's better at reducing relapses. It's been a rough 2 years for me so it's not just changing for the sake of it. Granted, I do credit getting on copaxone early with why I'm doing well after 10 years.

Well it most certainly is not safer than cop, as it requires baseline cbc levels, causes a 30% reduction of lymphocytes and has a history of pml in europe with lighter/episodic use for skin issues, massive GI issues that led to more discontinuations than Cop in an active comparator trial and even though not for direct comparison, the relapse rate reduction was 0.06 different...basically the same for this measure and of course cop's long term efficacy and its effect on the degenerative processes not just inflammatory metrics is huge. Just my thoughts based on my sister's treatments.

[PapaBear]

Look what I'm picking up in Rockville, MD tomorrow! 2006, 91K, 4WD.

http://i6.photobucket.com/albums/y229/snowmaninva66/element1_zpsb2d7ef67.jpg

[spoon]

does it come with anal sex and the herp?

looks like it!


:tongue:

[PapaBear]

does it come with anal sex and the herp?

looks like it!


:tongue:
My brother has one, and I love it. You can haul a surprising amount in it, for being fairly small. It's also highly rated for dog owners, since it's so easy to clean out the back. I just can't believe I went from having a zero credit rating a few months ago, to being able to get a car loan from a place that doesn't do themselves (like JD Byrider). Those places are rip offs, and have shitty cars.

[PapaBear]

Oh, and it's very highly rated safety-wise. So I can finally start driving like a maniac again. In my Prizm, I felt like I was a victim waiting to happen.

[spoon]

Oh, and it's very highly rated safety-wise. So I can finally start driving like a maniac again. In my Prizm, I felt like I was a victim waiting to happen.

that car has to smell like that magical combo of wet dog, old man and stale pizza

so yah, upgrade...just a gay one

:wink:

[PapaBear]

that car has to smell like that magical combo of wet dog, old man and stale pizza

so yah, upgrade...just a gay one

:wink:
I never carried my dog when he was wet, I smell divine, and the cigarette smoke negates any pizza smell. I'm giving the unsafe Prizm to my daughter.

[spoon]

oh wow, she'll be thrilled!

you might as well just give her a yearly subscription to Prism too while you're at it

http://24.media.tumblr.com/tumblr_loriqdHWGe1qch9gxo1_500.jpg

http://4192cards.com/rose/mags/magse-r/images/Prism%20TV%20Guide%201982%20-%20Apr.jpg

[PapaBear]

She is excited. Her current vehicle is a piece of shit. It's cheaper for me to give her this car (rather than trade it in), and not have to keep sending her money for repairs. I hope she can sell the battery I bought her last night.

[jennysmurf]

that car has to smell like that magical combo of wet dog, old man and stale pizza

so yah, upgrade...just a gay one

:wink:

:laugh:

[PapaBear]

:laugh:
I expect it from spoon. From you, it hurts.

[jennysmurf]

I expect it from spoon. From you, it hurts.

I'm just laughing out of hurt. I gave you my heart and you spurned me....a lot. So I retaliate by trying to make you seem more unnatractive.

[PapaBear]

I retaliate by trying to make you seem more unnatractive.
Not a chance, when my new car matches my stylin' Ray Bans.

[jennysmurf]

Not a chance, when my new car matches my stylin' Ray Bans.

I'm gonna have to arm wrestle spoon for shotgun.

[PapaBear]

I'm gonna have to arm wrestle spoon for shotgun.
I said it's a popular car for dog owners. I'm going to put spoon in a cage in the back.

[deliciousV]

I said it's a popular car for dog owners. I'm going to put spoon in a cage in the back.

he'll still mange to piss all over the place

[jennysmurf]

I said it's a popular car for dog owners. I'm going to put spoon in a cage in the back.

ROAD TRIP!!

[PapaBear]

he'll still mange to piss all over the place
Once again... You can hose out the back without worry. And I don't plan on taking him out before I turn the garden hose on it.

[jennysmurf]

Once again... You can hose out the back without worry. And I don't plan on taking him out before I turn the garden hose on it.

Well, you'd better map out all the gas stations with free water from where you are to California--cause you're driving out here to visit me, aren't you?

[PapaBear]

Well, you'd better map out all the gas stations with free water from where you are to California--cause you're driving out here to visit me, aren't you?
I do plan to start road tripping as much as possible.

[deliciousV]

I do plan to start road tripping as much as possible.

head south and pick me up, we can road trip and disappoint Jenny at the same time.

[jennysmurf]

head south and pick me up, we can road trip and disappoint Jenny at the same time.

:laugh: Story of my life!

[keithy_19]

Hiv!

[jennysmurf]

Hiv!

Your test results came back?

[keithy_19]

Your test results came back?

I'm just waiting for the diagnosis of AIDS.

I was going to post in the drunk thred, but I think I'm just going to go to bed. A whole lot of shots and I just took an ambien. Because it makes sense to do things like that.

:bye:

[jennysmurf]

I'm just waiting for the diagnosis of AIDS.

I was going to post in the drunk thred, but I think I'm just going to go to bed. A whole lot of shots and I just took an ambien. Because it makes sense to do things like that.

:bye:

Nighty night, sugar buns.

[PapaBear]

I was going to post in the drunk thred, but I think I'm just going to go to bed. A whole lot of shots and I just took an ambien. Because it makes sense to do things like that.

:bye:
Quit drinking and I seem to be making a lot of them.

Ok... You post in the drunk thread that you don't drink, and then you post here that you're drunk? Or, were the shots for rabies, or something?

[jennysmurf]

Ok... You post in the drunk thread that you don't drink, and then you post here that you're drunk? Or, were the shots for rabies, or something?

Get outta here with your voice of reason and stuff.

[PapaBear]

does it come with anal sex and the herp?

looks like it!


:tongue:
BTW... I picked it up today. It's fucking BEAUTIFUL!

[jennysmurf]

BTW... I picked it up today. It's fucking BEAUTIFUL!

Did they see you rollin'? Were they hatin'? Did they catch you ridin' dirty?

[PapaBear]

Did they see you rollin'? Were they hatin'? Did they catch you ridin' dirty?
Driving on the Capital Beltway for the first time in about 14 years, in a vehicle that I had driven for a total of about 5 miles, it's more likely the caught me driving too slow, and trying to figure out which of the fifteen million lanes I was supposed to be in. Why the FUCK was the beltway so busy on a Sunday evening? :furious:

[jennysmurf]

Driving on the Capital Beltway for the first time in about 14 years, in a vehicle that I had driven for a total of about 5 miles, it's more likely the caught me driving too slow, and trying to figure out which of the fifteen million lanes I was supposed to be in. Why the FUCK was the beltway so busy on a Sunday evening? :furious:

You old folks should stick to the neighborhood streets.

[PapaBear]

You old folks should stick to the neighborhood streets.
I actually tried that. My GPS wouldn't let me do that. Every time I put in an exclusion, it came up with another crazy Interstate to use. It actually wasn't too bad. I just had to get used to the difference in what's viewable with the new car, compared to my old one.

[jennysmurf]

Just looking through some of the photo galleries. What happened to all the people that used to be here? How dare they move on with their lives!

[PapaBear]

Just looking through some of the photo galleries. What happened to all the people that used to be here? How dare they move on with their lives!
I always enjoy clicking on the one with Flash's girlfriend. HUMMINAHUMMINAHUMMINA!!!

[keithy_19]

Ok... You post in the drunk thread that you don't drink, and then you post here that you're drunk? Or, were the shots for rabies, or something?

It was my friend's birthday and I said screw it. I paid for it today, but that's OK. And no bad decisions so that's a plus.

[jennysmurf]

I always enjoy clicking on the one with Flash's girlfriend. HUMMINAHUMMINAHUMMINA!!!

That's the only thing that makes me glad I never went to any events when I lived there. If half the people here knew what I looked like, they'd never talk to me again.

[keithy_19]

That's the only thing that makes me glad I never went to any events when I lived there. If half the people here knew what I looked like, they'd never talk to me again.

She's lovely. And very Hispanic.

[PapaBear]

She's lovely. And very Hispanic.
His panic is a result of all of her stalking.

[realmenhatelife]

So three of us are walking into the building at the same time this morning. First dude who looks like Meatloaf from the 70s, same face long hair leather jacket. He might be 30 but that's a look that ages you so It's hard to say. Probably 15 seconds behind him is an attractive, mid 20s girl in heels and a short flowy skirt on a windy day, and then two strides behind her is me.

We're discouraged from holding the door open for eachother because of these new security protocols, that are generally pissing everyone off. Well, meatloaf is holding the door for the girl, and I mean it's a good fifteen or twenty seconds while he just watches her mince on her heels across the parking lot, and she even kindof makes a noise like 'I'm way too far away so just drop the door because I'm uncomfortable now' but meat wont hear it. It's long enough for uncomfortable silence, he makes a joke about holding the door and flaunting the rules, uncomfortable silence.

So she finally gets there, and I'm two strides behind her, and boom meat drops the door in my face to follow cutsie through the lobby to try and flirt with her. The door didn't even latch before I grabbed it.

[realmenhatelife]

And I watched some of that Katy Perry movie while I was working out and Russell Brand is just a monster.

[Chigworthy]

So three of us are walking into the building at the same time this morning. First dude who looks like Meatloaf from the 70s, same face long hair leather jacket. He might be 30 but that's a look that ages you so It's hard to say. Probably 15 seconds behind him is an attractive, mid 20s girl in heels and a short flowy skirt on a windy day, and then two strides behind her is me.

We're discouraged from holding the door open for eachother because of these new security protocols, that are generally pissing everyone off. Well, meatloaf is holding the door for the girl, and I mean it's a good fifteen or twenty seconds while he just watches her mince on her heels across the parking lot, and she even kindof makes a noise like 'I'm way too far away so just drop the door because I'm uncomfortable now' but meat wont hear it. It's long enough for uncomfortable silence, he makes a joke about holding the door and flaunting the rules, uncomfortable silence.

So she finally gets there, and I'm two strides behind her, and boom meat drops the door in my face to follow cutsie through the lobby to try and flirt with her. The door didn't even latch before I grabbed it.

He didn't wait all that time to get a look at the hipsters ass, only to blow it by helping you out.

[realmenhatelife]

He didn't wait all that time to get a look at the hipsters ass, only to blow it by helping you out.

I think he waited so long he forgot that the ruse is "I'm a nice guy who holds the door for people so talk to me in the elevator" not "I'm transparently entrapping you into talking to me for the next 45 seconds."

[Chigworthy]

I think he waited so long he forgot that the ruse is "I'm a nice guy who holds the door for people so talk to me in the elevator" not "I'm transparently entrapping you into talking to me for the next 45 seconds."

Anyone who dresses like Meatloaf is more likely to have the ruse that "I'm a nice guy who holds the door for hot ass and don't give a fuck if other people see through my ruse as long as I get to follow this Zooey Deschanel clone to the elevator".

[jennysmurf]

And I watched some of that Katy Perry movie while I was working out and Russell Brand is just a monster.

Right...."working out" That what the kids are calling it these days?

[realmenhatelife]

Right...."working out" That what the kids are calling it these days?

There's no spank material there, it might as well have been j.smurfs underwear drawer.

[Gutter]

There's no spank material there, it might as well have been j.smurfs underwear drawer.

Rule #34

[jennysmurf]

There's no spank material there, it might as well have been j.smurfs underwear drawer.

:laugh:It is pretty grim in there...


Rule #34


People are terrible.

[Gutter]

Rule #34

People are terrible.

Oh, so you're familiar with that rule then? haha

[jennysmurf]

Oh, so you're familiar with that rule then? haha

I know things.

[Gutter]

I know things.

I know stuff about things too and stuff.

[jennysmurf]

I know stuff about things too and stuff.

We're smaht.

[Gutter]

We're smaht.

wicked smaht.

[jennysmurf]

OKCupid just matched me with a guy named "fattypneumoia." I sent him a message asking him if his Dad cleaned the sand out of his butt with a garden hose. Love. Exciting and new. Come aboard. We're expecting yoooooooou!

[PapaBear]

OKCupid sounds like the name of one of those faggy bands that use the word "punk" these days.

[jennysmurf]

OKCupid sounds like the name of one of those faggy bands that use the word "punk" these days.

Since you spurned me, I must look for love elsewhere.

[jennysmurf]

https://i.chzbgr.com/maxW500/7316470784/h7FFDCC8B/

[PapaBear]

Cookies and cream shakes are hack.

[jennysmurf]

Cookies and cream shakes are hack.

It's better than your's.

[PapaBear]

It's better than your's.
I'm happy with my Drumstick.

http://i6.photobucket.com/albums/y229/snowmaninva66/drumstick_zpsf42fcba1.jpg

[PapaBear]

I was going to specify that it's a chocolate Drumstick, but I sensed the impending black cock jokes.

[jennysmurf]

I was going to specify that it's a chocolate Drumstick, but I sensed the impending black cock jokes.

So you're saying you like your drumsticks....brown...with nuts?

[PapaBear]

So you're saying you like your drumsticks....brown...with nuts?
And also vanilla/caramel.

[jennysmurf]

And also vanilla/caramel.

Gay.

[PapaBear]

Gay.
Fine. You get NONE!

[jennysmurf]

Fine. You get NONE!

Story of my life!

[PapaBear]

I don't understand fast food combo meals that come with ice cream. Are you supposed to eat the food like a pig before the desert melts, or eat the ice cream first like some sort of moron?

[jennysmurf]

I don't understand fast food combo meals that come with ice cream. Are you supposed to eat the food like a pig before the desert melts, or eat the ice cream first like some sort of moron?

Maybe eat them at the same time? Like a big 'ol burger and fries Blizzard.

[PapaBear]

Maybe eat them at the same time? Like a big 'ol burger and fries Blizzard.
That's just nonsense. A shake, is fine, but this Dairy Queen commercial I just saw showed a sundae, burger, and fries. No way I could eat a sundae with a burger and fries.

[jennysmurf]

That's just nonsense. A shake, is fine, but this Dairy Queen commercial I just saw showed a sundae, burger, and fries. No way I could eat a sundae with a burger and fries.

Don't be so closed-minded. Now I'm starvin.

[PapaBear]

Don't be so closed-minded. Now I'm starvin.
If you hadn't been mean, you'd be eating a vanilla/caramel Drumstick right now.

[jennysmurf]

If you hadn't been mean, you'd be eating a vanilla/caramel Drumstick right now.

Liar. You'd just show me a picture of it, then tell me it was in love with someone else.

[PapaBear]

Liar. You'd just show me a picture of it, then tell me it was in love with someone else.
It loves no one. It's sitting alone, atop a pile of frozen waffles.

[jennysmurf]

It loves no one. It's sitting alone, atop a pile of frozen waffles.

Weird. I'm doing the same thing.

[PapaBear]

Weird. I'm doing the same thing.
Is it that hot there? Ever hear of air conditioning?

[keithy_19]

Liar. You'd just show me a picture of it, then tell me it was in love with someone else.

It's OK. He said the same thing to me.

[jennysmurf]

It's OK. He said the same thing to me.

He's a whore.

[sailor]

https://i.chzbgr.com/maxW500/7316470784/h7FFDCC8B/

Cookies and cream shakes are hack.

He's too old for your joke.

[spoon]

Fine. You get NONE!

of course

she's a girl

[jennysmurf]

He's too old for your joke.

Yeah, Papabear's old.

[deliciousV]

Though I will be roundly criticized for saying it, I think if Sam could get DJ Whoo Kid to to a regular show with him, it would be successful. Obviously Whoo Kid is making too much money doing his thing to stop doing it and be a daily radio guy, but when he is on with Sam I laugh, a lot.

[deliciousV]

All of the Whoo Kid black history month bits, go ahead, pretend that shit ain't funny son!

<iframe width="420" height="315" src="http://www.youtube.com/embed/upNljmPrDIk" frameborder="0" allowfullscreen></iframe>

[Dell]

Though I will be roundly criticized for saying it, I think if Sam could get DJ Whoo Kid to to a regular show with him, it would be successful. Obviously Whoo Kid is making too much money doing his thing to stop doing it and be a daily radio guy, but when he is on with Sam I laugh, a lot.

Whoo Kid and Sam are hilarious...I love Sam's sarcasm but his love of Wrestling takes away from that

when Sam is on with Whoo Kid, I laugh my ass off because it is very little Wrestling talk...especially when the lady is on with them (Nichol, I think) because she rolls with everything!

since Whoo Kid is an almost regular member on the After Show...it gives me even more reason to hate the Wednesday Advice Show

[Dell]

All of the Whoo Kid black history month bits, go ahead, pretend that shit ain't funny son!

<iframe width="420" height="315" src="http://www.youtube.com/embed/upNljmPrDIk" frameborder="0" allowfullscreen></iframe>

yep...Prime Time and Whoo Kid need there own show

[deliciousV]

Sam's Wednesday show is really the best

[spoon]

yah, not so much on those bits

oof

[deliciousV]

yah, not so much on those bits

oof

meh, you hate everything. Yo, that shit's funny son!

[spoon]

no

i hate hatable shit, this qualifies plenty

like your awful post dialogue yo

[jennysmurf]

no

i hate hatable shit, this qualifies plenty

like your awful post dialogue yo

Stop trying to pick fights with the drunks.:nono: Wait until Papabear signs in, then fight with him.

[deliciousV]

no

i hate hatable shit, this qualifies plenty

like your awful post dialogue yo

admit it, you're just a troll. Here to argue with everybody, and shit on everything. Just stop pretending.

[keithy_19]

http://www.tgttm.com/jefferton/download/file.php?avatar=16567_1334264419.png

[jennysmurf]

http://www.tgttm.com/jefferton/download/file.php?avatar=16567_1334264419.png

What did you do this time?

[PapaBear]

He's too old for your joke.
No I'm not. I just would have picked a more appetizing shake.

[keithy_19]

What did you do this time?

Actually nothing. I'm just assuming that I'll probably mess up sometime soon and this is a premptive measure.

[jennysmurf]

Actually nothing. I'm just assuming that I'll probably mess up sometime soon and this is a premptive measure.

Ah, always good to be prepared.

[keithy_19]

Ah, always good to be prepared.

With that said good things seem to be coming my way. So, maybe I won't. I'm excited.

[jennysmurf]

With that said good things seem to be coming my way. So, maybe I won't. I'm excited.

Excited in a sexy way?

[keithy_19]

Excited in a sexy way?

Well, at the moment paink killers are making everything just great (legally prescribed) and so if that's sexy, I guess that's pretty cool. And it involves me acting so if that's sexy, then, well, sure.

[spoon]

admit it, you're just a troll. Here to argue with everybody, and shit on everything. Just stop pretending.



Ahhhh. Someone is licking dspy asshole now i get it. Have fun with that, I'll have fun with my opinions that make pussies like you weep so. Sorry it's sooooo hard for you when another disagrees with your stupid gun policy and a few promos that are hack. But hey, you're just an ass licker. Why don't you just admit you like licking man ass and sucking up is your crutch. And you think I pretend to be what? That's hilarious! We all can't come up with original defenses to SIMPLE disagreements like you by screaming that oh so original/weak "troll" bullshit too. Thanks ron! You don't agree = troll! Ha! Well you just fed me you stupid cunt.

[spoon]

Stop trying to pick fights with the drunks.:nono: Wait until Papabear signs in, then fight with him.



Hate those awful bits he loved and said as much, hardly picking a fight. Coming at me for my op, yah that is more the case and i can have plenty of fun with my retort in fine "troll" fashion. One gets what one requests. His reaction is quite righteous and out of nowhere about some DUMB bits. There is an underlying bullshit to it all, and it's pretty clear dv likes to snap the fuck out often and ties into other things. I'll show him the same courtesy now.

[Gutter]

This whole day can eat shit....a big bag of shit.

[spoon]

http://niketalk.com/content/type/61/id/144426/width/500/height/1000/flags/LL

:lol:

with the one exception of hate I presume!?

[Chigworthy]

This whole day can eat shit....a big bag of shit.

I had similar thoughts today. I was driving down the freeway thinking "fuck you" to every person I saw, so I pulled this up on my phone:

<iframe width="560" height="315" src="http://www.youtube.com/embed/wOHA6j_PLrk" frameborder="0" allowfullscreen></iframe>

[keithy_19]

As all this bickering is going on all I know is that I'm very excited for sleep. Goodnight folks. :bye:

[jennysmurf]

As all this bickering is going on all I know is that I'm very excited for sleep. Goodnight folks. :bye:

So early?

[spoon]

He has to eat some poop.

[jennysmurf]

He has to eat some poop.

Well that's just silly.

[spoon]

I just figured that was his tag. Oh well.

[jennysmurf]

I just figured that was his tag. Oh well.

:laugh: That was JayW's tag. I'm not gonna guess at the backstory to that one.

[realmenhatelife]

<iframe width="560" height="315" src="http://www.youtube.com/embed/EOnc0xCnnkc" frameborder="0" allowfullscreen></iframe>

Jimmy Fallon is the worlds worst actor.

[keithy_19]

So early?

It happens. I'm taking some new medicine that tuckers me out. Figured I might as well sleep rather than fight it off.

[deliciousV]

I keep accidentally opening the my radio link on the left, then I noticed how far up that link goes, almost to the iSpy button. Well played .net, well played. lot's of clicks.

[keithy_19]

Well it most certainly is not safer than cop, as it requires baseline cbc levels, causes a 30% reduction of lymphocytes and has a history of pml in europe with lighter/episodic use for skin issues, massive GI issues that led to more discontinuations than Cop in an active comparator trial and even though not for direct comparison, the relapse rate reduction was 0.06 different...basically the same for this measure and of course cop's long term efficacy and its effect on the degenerative processes not just inflammatory metrics is huge. Just my thoughts based on my sister's treatments.

I got this from the NMSS

FAQ About FDA’s Approval of Oral Dimethyl Fumarate – Brand name Tecfidera™ – for Relapsing MS
FAQs Updated 4/3/13

Q. What is Tecfidera?
A. Tecfidera is an oral therapy contained in capsules taken two times per day. Tecfidera, formerly known as BG-12, is dimethyl fumarate, a formulation that was developed specifically for use by people with multiple sclerosis. A chemically related compound, called Fumaderm (dimethyl fumarate and fumaric acid esters), has been used at higher doses for decades in Germany to treat acute flare-ups of psoriasis. Although its exact mechanism of action is not known, Tecfidera is thought to inhibit immune cells and molecules, and may have anti-oxidant properties that could be protective against damage to the brain and spinal cord.

Q. What types of MS is Tecfidera approved to treat?
A. The FDA has approved Tecfidera for the treatment of patients with relapsing forms of MS. In other words, people who experience periodic MS attacks, such as those who have relapsing-remitting MS or secondary-progressive MS with relapses.

Q. How is Tecfidera taken?
A. The capsules are taken orally twice per day. When Tecfidera is begun, individuals will be provided with a one-week reduced starter dose, and thereafter a maintenance dose, both taken twice daily.

Q. When will Tecfidera be available by prescription?
A. Tecfidera is now available by prescription.

Q. How effective is Tecfidera?
A. In phase III clinical trials of Tecfidera capsules, Tecfidera significantly reduced the proportion of people who experienced relapses at 2 years, compared with those on placebo. Those on the twice-daily dose had a 49% reduction in the risk of relapse compared to those on placebo. Tecfidera also reduced the average annual number of relapses (annualized relapse rate) by 44% compared to placebo. The therapy also had a significant impact on disease activity detected with MRI. In one of two phase III trials, Tecfidera also reduced the risk of confirmed progression of disability (detected by the EDSS, a standard scale that measures disability). The proportion of those who progressed over two years was 16% for twice-daily Tecfidera versus 27% for placebo -- a 38% reduction in the risk of disability.

Q. What are the potential side effects of Tecfidera?
A. Tecfidera may cause flushing (which can create a sensation of heat or itching and a red blush on the skin) and gastrointestinal events (such as diarrhea, nausea, and upper abdominal pain). The incidence of these events during clinical trials was highest in the first month of treatment, decreasing thereafter. Taking Tecfidera with food may reduce flushing. Tecfidera reduced blood lymphocyte (white blood cell) counts but no significant or severe infections were reported. The Prescribing Information (.pdf) provides full information on potential side effects.

Q. Why should a person with MS consider taking a disease-modifying therapy?
A. Taking a disease-modifying therapy is currently the best way to reduce MS disease activity and future deterioration. Studies comparing people in clinical trials who started therapy earlier than those on inactive placebo suggest that early treatment offered important benefits against the accumulation of disability, which were generally not experienced to the same degree by those who started treatment later. .

Selecting an MS therapy should be done by people with MS in collaboration with their MS doctors, taking into account a variety of factors, including the effectiveness of any therapy they are currently using, and weighing potential risks and benefits, costs and lifestyle factors.

Q. Should I switch from my current therapy to Tecfidera?
A. The decision about whether to take Tecfidera should be made in collaboration with your MS doctor, taking into account a variety of factors including the effectiveness of any therapy you are currently using, the potential risks and benefits, as well as costs and lifestyle factors. Important questions to be considered and discussed with your doctor in terms of Tecfidera include:
• How am I doing on my current therapy?
• What is my tolerance for the risk of known side effects?
• What is my tolerance for the risk of adverse consequences that might emerge with longer-term use?
• How will my medication choice affect my ability or plans to become pregnant?
• What are the comparative costs of my current therapy versus Tecfidera?

Q. How does the effectiveness of Tecfidera compare to other available therapies?
A. Tecfidera has not been compared in head-to-head trials to other available therapies. Although one group during the CONFIRM clinical trial was receiving glatiramer acetate (Copaxone®, Teva Pharmaceutical Industries) as a reference, the study was not designed to compare the effectiveness of Tecfidera versus Copaxone.

[CountryBob]

Angie Miller on American Idol is my kinda redneck hot!

[PapaBear]

I got recognized from Facebook yesterday. A chick at work asked if my last name was McClure. Never having seen her before, I was surprised that she knew my name. She said she saw something that I wrote to a mutual FB friend. It's kind of a weird feeling.

[jennysmurf]

I got recognized from Facebook yesterday. A chick at work asked if my last name was McClure. Never having seen her before, I was surprised that she knew my name. She said she saw something that I wrote to a mutual FB friend. It's kind of a weird feeling.

You're a weird feeling.

[PapaBear]

You're a weird feeling.
You're a you're.

[jennysmurf]

You're a you're.

*sticks tongue out at papabear

[PapaBear]

*sticks tongue out at papabear
*grabs jenny's tongue and starts doing jumping jacks

[jennysmurf]

*grabs jenny's tongue and starts doing jumping jacks

Ouch! You're so mean!

[sailor]

Ouch! You're so mean!

You're an ouch.

[jennysmurf]

You're an ouch.

Curses, foiled again!

[PapaBear]

I'm checking out my car's owner's manual for the first time. I just learned, if I remove the front headrests, the front seats fold down in line with the rear seats to make one long cushion. I have a camper!!!

[jennysmurf]

I'm checking out my car's owner's manual for the first time. I just learned, if I remove the front headrests, the front seats fold down in line with the rear seats to make one long cushion. I have a camper!!!

Throw a mattress in the back, and you're on your way! (to California)

[PapaBear]

Throw a mattress in the back, and you're on your way! (to California)
You're missing the point. I don't need a mattress. The seats basically become two single beds.

[jennysmurf]

You're missing the point. I don't need a mattress. The seats basically become two single beds.

Not comfy enough. Bring a mattress.

[realmenhatelife]

I've been googling a lot of info on Ball Bearings this morning for bicycle purposes, I feel like I'm gonna get put on some watch list.

[Gutter]

I've been googling a lot of info on Ball Bearings this morning for bicycle purposes, I feel like I'm gonna get put on some watch list.

You're not already on some watch list?

[sailor]

So fucking cold in our office today.

[realmenhatelife]

You're not already on some watch list?

Not for this, anyway.

So fucking cold in our office today.

I miss having a cold office. I'm on the top floor now so it's always piss hot and the water cooler just comes out as a trickle.

[Misteriosa]

why is it these callers to jim's show want their girlfriends to do some kind of surgery because they find the vag lips to be too big/not tight enough or something like that?

i would think they would be glad just to be allowed in the area :unsure:

[realmenhatelife]

why is it these callers to jim's show want their girlfriends to do some kind of surgery because they find the vag lips to be too big/not tight enough or something like that?

i would think they would be glad just to be allowed in the area :unsure:

Guys who think it's reasonable to request vaginoplasty are surprisingly lacking in self awareness of their attractiveness to other women?

[Misteriosa]

Guys who think it's reasonable to request vaginoplasty are surprisingly lacking in self awareness of their attractiveness to other women?

im also guessing that these guys are not considering that these women might even have a sex life with other men when its over.

[A.J.]

why is it these callers to jim's show want their girlfriends to do some kind of surgery because they find the vag lips to be too big/not tight enough or something like that?

i would think they would be glad just to be allowed in the area :unsure:

So hot.

[sailor]

why is it these callers to jim's show want their girlfriends to do some kind of surgery because they find the vag lips to be too big/not tight enough or something like that?

i would think they would be glad just to be allowed in the area :unsure:

People want other people to change for them. Sure, this is pretty far over toward the extreme/drastic, but it's on the same sliding scale as wanting your S.O. to lose weight, get a haircut, get better clothes, etc.

[Misteriosa]

People want other people to change for them. Sure, this is pretty far over toward the extreme/drastic, but it's on the same sliding scale as wanting your S.O. to lose weight, get a haircut, get better clothes, etc.

thing is, today's call was not the first time that topic was brought up. it boggles my mind.

"your most intimate of areas, which i am privileged to have access to, does not meet my aesthetic standards! Have this expensive vaginal cosmetic procedure and please me."

[spoon]

thing is, today's call was not the first time that topic was brought up. it boggles my mind.

"your most intimate of areas, which i am privileged to have access to, does not meet my aesthetic standards! Have this expensive vaginal cosmetic procedure and please me."


they probably want the lips molded into a penis

the better question is, wwjd?

:innocent:

[keithy_19]

It only took me less than a month away from turning 25 but I feel like an adult now.

[jennysmurf]

It only took me less than a month away from turning 25 but I feel like an adult now.

You'll always be barely legal to me.:wub:

[keithy_19]

You'll always be barely legal to me.:wub:

:wink: Let's hang out and make a video...

I'm typing right now in a khakis a collared shirt and a tie. I had to go to a two hour meeting today as well. I feel good about it.

[iSpider]

Huh...

[BlackSpider]

Huh...

Huh indeed...

[PapaBear]

I've been googling a lot of info on Ball Bearings this morning for bicycle purposes, I feel like I'm gonna get put on some watch list.
Google should have a function where you can follow your search inquiry with, "Pretend I'm normal", and it would filter out anything that uses slang.

[ozzie]

I've been googling a lot of info on Ball Bearings this morning for bicycle purposes, I feel like I'm gonna get put on some watch list.

http://a3.ec-images.myspacecdn.com/images01/26/a0ef6bb044a220d6b73fdf34549647e0/l.jpg

It's all ball bearings nowadays.

[jennysmurf]

:wink: Let's hang out and make a video...

I'm typing right now in a khakis a collared shirt and a tie. I had to go to a two hour meeting today as well. I feel good about it.

So sexy. :wub:

[jennysmurf]

Huh indeed...

Quoting yourself is so get.

[PapaBear]

a collared shirt
Did you get it at one of those "urban" stores?

http://1.bp.blogspot.com/-KsZruXbUctY/Tx71fWxjtTI/AAAAAAAABE4/0-a1h9sI7vQ/s1600/AniDiFrancoCROP.jpg

[jennysmurf]

Did you get it at one of those "urban" stores?

http://1.bp.blogspot.com/-KsZruXbUctY/Tx71fWxjtTI/AAAAAAAABE4/0-a1h9sI7vQ/s1600/AniDiFrancoCROP.jpg

Boooooo...:thumbdown:

[PapaBear]

I just realized she has a white pussy.

[keithy_19]

So sexy. :wub:

If I can speak kindly about myself, I look dapper at the moment.

[BlackSpider]

Quoting yourself is so get.

You're get...

[jennysmurf]

I just realized she has a white pussy.

http://www.srpl.net/images/slap.jpg

[jennysmurf]

You're get...

So's your face!

[spoon]

White pussy is great as long as it's not all lippy...right misti!

[jennysmurf]

White pussy is great as long as it's not all lippy...right misti!

Aw man! You'd better hope she doesn't peruse this thread when she comes back!

[keithy_19]

So yesterday I said how for the first time I finally felt like an adult. Today I got a summons for jury duty. Go fucking figure.

[jennysmurf]

So yesterday I said how for the first time I finally felt like an adult. Today I got a summons for jury duty. Go fucking figure.

Technically, you asked for it. Just tell them you want to bring back hanging as a form of capital punishment. Should get you excused.

[deliciousV]

So yesterday I said how for the first time I finally felt like an adult. Today I got a summons for jury duty. Go fucking figure.

shave your head, wear a black T-shirt with a white power fist on the front. You'll be out before lunch time.

[keithy_19]

shave your head, wear a black T-shirt with a white power fist on the front. You'll be out before lunch time.

I was just gonna go in black face.

[deliciousV]

I was just gonna go in black face.

also effective

[jennysmurf]

I'm glad Keithy has us to come to for good advice.

[sailor]

I'm glad Keithy has us to come to for good advice.

Serious answers only, people.

[jennysmurf]

Serious answers only, people.

Psh, whatevs, old man.

[spoon]

man?

again, serious replies only please

[keithy_19]

Cream soda is fucking delicious.

[spoon]

Cream is fucking delicious.

you fez!!

[deliciousV]

Cream soda is fucking delicious.

Whazzat?

[PapaBear]

I'm not usually a huge fan of Tea Leoni, but she's fucking HOT in Bad Boys!


Yeah... It took me 18 years to gt around to watching it. I've always been annoyed when I see "Bad Boys" on the TV channel guide, only to find out that it's not 1983 Sean Penn flick.

[spoon]

come on, it has the black knight in it!

[cougarjake13]

I'm not usually a huge fan of Tea Leoni, but she's fucking HOT in Bad Boys!


Yeah... It took me 18 years to gt around to watching it. I've always been annoyed when I see "Bad Boys" on the TV channel guide, only to find out that it's not 1983 Sean Penn flick.


god damn where has she been ?
I know she did some movies after that but damned if I know


and in that movie with the white tee shirt

yummy

[Fez4PrezN2008]

Hey can one or more of you post over at V3 in the 2nd annual show up and post thread to say hi? Tell them Sigma sent you. Thanks.

[keithy_19]

Hey can one or more of you post over at V3 in the 2nd annual show up and post thread to say hi? Tell them Sigma sent you. Thanks.

Nope.

[spoon]

Nope.

x 2

you better ask Udog the backslider!

[underdog]

x 2

you better ask Udog the backslider!

Wait, what did I do now?

[spoon]

Wait, what did I do now?

http://25.media.tumblr.com/tumblr_lsks5t758p1qzga0mo1_500.png

[underdog]

http://25.media.tumblr.com/tumblr_lsks5t758p1qzga0mo1_500.png

Whatever happened to that asian chick that posted all those youtube videos about being a pussy?

[underdog]

Also, just got my first hole in one on Tiger Wood '14.

[spoon]

Also, just got my first hole in one on Tiger Wood '14.

wow

what a day!

:wallbash:

[spoon]

Whatever happened to that asian chick that posted all those youtube videos about being a pussy?


he's/she's watching soccer

[realmenhatelife]

I caught a few minutes of Jason Ellis driving around on Sunday and he was interviewing Andy Milonakis and someone very earnestly called in to ask if they were ever going to make a third movie in the "Waiting" franchise. Actually, I believe his exact words were "are they going to make a sequel to Still Waiting..."

[spoon]

yep, another case of lucky the first one came out well

[CountryBob]

Just noticed that HTG looks a lot like old Blossom in the Big Bang Theory

[sailor]

Just noticed that HTG looks a lot like old Blossom in the Big Bang Theory

Racist!

[spoon]

With a whole lot of philly cream cheese added.

[sailor]

Snl was funny with galifinakis. Didn't know samwell tarly had a band.

[Jayw]

I need a female. I try to blame it on what the big corps have termed it, social anxiety, but I just got to man up. I got a college degree and have always been ahead of the curve and popular but I let people with half the smarts and more balls run shit. I have always leaned towards drugs but lately ill chalk it up to getting older(3 years to 30 fuck), I want a fucking woman. Trying to lay off the blow and stay out of bad situations where i got to drive drunk.

Pray for me people of the internet, to man up and actually put myself out there and to take the pussy off the pedestal. I have zero debt, a credit score in the mid 800's, great parents(prolly half my problem), flawless vehicle, 10K cash, 45k in liquid investments, a blue collar job, with a white collar education. I banged a fat girl as a slumpbuster to try and break me out of this and that didn't even work. Put me in a bigger depression cause i was so drunk I went raw, but got tested the other day and 100% clear. And she says shes on the shot, i fucking hope so. Man that will suck in a few months if I find out different.

Don't really know what the purpose of this is, other than to brag and bitch about what other people would die to have.

If you're reading this then fuck you, d bag.

[spoon]

your "fat" girl may be getting bigger soon...unlike your package!

ohhhhhhh!

:wink:


seriously though, good luck

quitting the drugs and drunk driving are a no brainer start

get to it

[jennysmurf]

Fat girls need love too.:glurps:

[sailor]

Fat girls need love too.:glurps:

That's not how the song goes!

[jennysmurf]

That's not how the song goes!

Samantha Fox wouldn't know nothing about that.

[A.J.]

Fat girls need love too.:glurps:

That was my thinking in college. :drunk:

[realmenhatelife]

I need a female. I try to blame it on what the big corps have termed it, social anxiety, but I just got to man up. I got a college degree and have always been ahead of the curve and popular but I let people with half the smarts and more balls run shit. I have always leaned towards drugs but lately ill chalk it up to getting older(3 years to 30 fuck), I want a fucking woman. Trying to lay off the blow and stay out of bad situations where i got to drive drunk.

Pray for me people of the internet, to man up and actually put myself out there and to take the pussy off the pedestal. I have zero debt, a credit score in the mid 800's, great parents(prolly half my problem), flawless vehicle, 10K cash, 45k in liquid investments, a blue collar job, with a white collar education. I banged a fat girl as a slumpbuster to try and break me out of this and that didn't even work. Put me in a bigger depression cause i was so drunk I went raw, but got tested the other day and 100% clear. And she says shes on the shot, i fucking hope so. Man that will suck in a few months if I find out different.

Don't really know what the purpose of this is, other than to brag and bitch about what other people would die to have.

If you're reading this then fuck you, d bag.

Is this your match.com profile?

[realmenhatelife]

Last night I had a dream that involved sex, peacocks, people I hate from high school, a condom that covers your balls, and hiding in a shower. It's all very Freudian.

[sailor]

a condom that covers your balls.

Wasn't that some Louis ck bit?

[realmenhatelife]

Wasn't that some Louis ck bit?

Maybe about magnums? I've definately seen jokes about this. This condom had like a seem in it and was fitted to the shape, not just stretched over it.

[sailor]

Maybe about magnums? I've definately seen jokes about this. This condom had like a seem in it and was fitted to the shape, not just stretched over it.

I think it was like that's how he thought they worked when he was a kid. May not have even used it in a show, but I think he discussed it on o&a.

[jennysmurf]

Last night I had a dream that involved sex, peacocks, people I hate from high school, a condom that covers your balls, and hiding in a shower. It's all very Freudian.

You may be gay. This was your subconscious giving you some hints.

[Gutter]

You may be gay. This was your subconscious giving you some hints.

How Freudian of you.

[jennysmurf]

How Freudian of you.

I took a psychology course in college.

[realmenhatelife]

You may be gay. This was your subconscious giving you some hints.

You wish I was gay because you're always talking about things being in your butt. And it was a girl. Although the sex was not fun.

[sailor]

And it was a girl. Although the sex was not fun.

She may be on to something, there.

[jennysmurf]

You wish I was gay because you're always talking about things being in your butt. And it was a girl. Although the sex was not fun.

http://troll.me/images2/napoleon-dynamite-farmer/i-dont-understand-a-word-you-just-said.jpg

[realmenhatelife]

http://troll.me/images2/napoleon-dynamite-farmer/i-dont-understand-a-word-you-just-said.jpg

I was trying to not say this so aggressively You wish I was gay so I'd do you in the butt

[jennysmurf]

I was trying to not say this so aggressively You wish I was gay so I'd do you in the butt

But if you were gay, you'd have no interest in me....wait, you already have no interest in me, so are you trying to tell me that you have a secret?

[sailor]

Oh yeah, spoilers also fuck up quoting on phones.

[realmenhatelife]

But if you were gay, you'd have no interest in me....wait, you already have no interest in me, so are you trying to tell me that you have a secret?

Well I didn't know the butt was in play.

[jennysmurf]

Oh yeah, spoilers also fuck up quoting on phones.

You and your phone. So many first world problems messing up our day.

[jennysmurf]

Well I didn't know the butt was in play.

Well it's not now, cause you're gay and probably have that meningitis.

[sailor]

You and your phone. So many first world problems messing up our day.

I'm not the only one!!

[Jayw]

I really hate this site not having a delete post option. Uncool

[Jayw]

I might need it in a little bit..... although I don't know how I could embarrass myself anymore.

[sailor]

I really hate this site not having a delete post option. Uncool

You could always ask. Or edit.

[sailor]

I wonder if DS got snow today.

[disneyspy]

it didnt stick

[realmenhatelife]

it didnt stick

the charges or the snow?

[keithy_19]

Good things happen sometimes :happy:

[jennysmurf]

Good things happen sometimes :happy:

Go oooooonn...:popcorn:

[keithy_19]

Go oooooonn...:popcorn:

I got offered an oppurtunity to teach acting/improv classes. I'm pretty excited for it.

[keithy_19]

I'm sorry if that's not nearly exciting enough.

[sailor]

Congrats!

[keithy_19]

Congrats!

Thanks! The most interesting part is I've never taken an acting class, let alone an improv class. I've acted since I was 6 but that's pretty much it. A director I've worked with for awhile now suggested I'd be good at it and put in a word for me. So, I don't know, maybe this leads into more stuff. I'm looking forward to it.

[jennysmurf]

Thanks! The most interesting part is I've never taken an acting class, let alone an improv class. I've acted since I was 6 but that's pretty much it. A director I've worked with for awhile now suggested I'd be good at it and put in a word for me. So, I don't know, maybe this leads into more stuff. I'm looking forward to it.

Yay! :clap:

[keithy_19]

Yay! :clap:

:wub:

And with that display of affection I'm going to try to get some sleep. Goodnight folks! :bye:

[jennysmurf]

:wub:

And with that display of affection I'm going to try to get some sleep. Goodnight folks! :bye:

Goodnight monkey. Have good sleeps.:wub:

[A.J.]

30 years ago today.

<iframe width="420" height="315" src="http://www.youtube.com/embed/gTqLENHzpME" frameborder="0" allowfullscreen></iframe>

[keithy_19]

Meeting people is hard.

[boobieman]

Watching this stuff with OK...it is down right scary...feel so bad for those people...just sad...just so sad

[jennysmurf]

Meeting people is hard.

Is that why you pretended to be sick when I was in town?

[deliciousV]

Is that why you pretended to be sick when I was in town?

he was just a little scared, you can be a little, you know, aggressive, sexually.

[spoon]

Is that why you pretended to be sick when I was in town?

he meant he only meats people when he's hard

yes, meat

[jennysmurf]

he was just a little scared, you can be a little, you know, aggressive, sexually.

Passive people don't get what they want.


he meant he only meats people when he's hard

yes, meat


Now you're just being silly.

[Chigworthy]

The gun issue has become just as fossilized as abortion and religion; there is literally no point in discussing it with people who disagree with you and there is almost no point in discussing it with people who agree with you. No one's mind will be changed, and discussion only serves as oratory masturbation.

[PapaBear]

When words used to be associated with old phone numbers, the first two letters of the word corresponded with the numbers on the phone. In old movies, they always used "KLondyke-5". K and L both fall under the number 5. Therefore, "KLondyke-5" means the number started with "555", the same three numbers that are always used in movies and TV today.

http://www.promoboxx.com/blog/wp-content/uploads//2012/10/the_more_you_know.jpeg

[keithy_19]

Is that why you pretended to be sick when I was in town?

I was really sick. I wouldn't lie about that.

I was limp though. I blame all anti-depressants I'm on. Though I'm sure I'd be able to get it up for you. I mean, it's always been a dream of mine to bang a Kentucky girl who lives in San Fran in a New York City Subway.

[jennysmurf]

I was really sick. I wouldn't lie about that.

I was limp though. I blame all anti-depressants I'm on. Though I'm sure I'd be able to get it up for you. I mean, it's always been a dream of mine to bang a Kentucky girl who lives in San Fran in a New York City Subway.

:laugh: Such a romantic! You're so adorable when you're messy and drunk. :wub:

[Jayw]

Meeting people is hard.

For real man, that shit was so easy when we were young, elementary-high school. Wish i didn't take that shit for granted, and I had the balls to start a facebook.

[keithy_19]

For real man, that shit was so easy when we were young, elementary-high school. Wish i didn't take that shit for granted, and I had the balls to start a facebook.

I'm young and all that, but it's just rough. Eh.

[Chigworthy]

White people who say that something or someone has been "put on blast" really need to think about the direction their life is going.

[sailor]

White people who say that something or someone has been "put on blast" really need to think about the direction their life is going.

you really...oh, nevermind.

[jennysmurf]

White people who say that something or someone has been "put on blast" really need to think about the direction their life is going.

I don't even know what that means. Maybe I'm too white.

[PapaBear]

I don't even know what that means. Maybe I'm too white.
I've only heard it a couple of times, too. And we are definitely white. Fo shizzle.

[PapaBear]

I'm about to start my fifth Volcano Taco from Taco Bell. Wish me luck. I prepared by pooping BEFORE eating them.

[jennysmurf]

I'm about to start my fifth Volcano Taco from Taco Bell. Wish me luck. I prepared by pooping BEFORE eating them.

You've eaten 5 of those things? You're gonna die out your bum-hole.

[PapaBear]

You've eaten 5 of those things? You're gonna die out your bum-hole.
We buy TP at Costco. I'm good.

[jennysmurf]

We buy TP at Costco. I'm good.

You should invest in a bidet.

[PapaBear]

You should invest in a bidet.
Bathroom isn't big enough.

[jennysmurf]

Bathroom isn't big enough.

Just feed the garden hose through the window.

[PapaBear]

Just feed the garden hose through the window.
Eh... I'll just use the Water Pik. :wink:

[jennysmurf]

Eh... I'll just use the Water Pik. :wink:

That's totes gross yo.

[PapaBear]

That's totes gross yo.
IKNOWRITE?